The severe hereditary progeroid disorder Cockayne syndrome is a consequence of a defective transcription‐coupled repair (TCR) pathway. This special mode of DNA repair aids a RNA polymerase that is stalled by a DNA lesion in the template and ensures efficient DNA repair to permit resumption of transcription and prevent cell death. Although some key players in TCR, such as the Cockayne syndrome A (CSA) and B (CSB) proteins have been identified, the exact molecular mechanism still remains illusive. A recent report (...) provides new unexpected insights into TCR in yeast.1 The identification and characterisation of a novel protein co‐purifying with the yeast homologue of CSB (Rad26) imposes reassessment of our current understanding of TCR in yeast. What about humans? BioEssays 24:780–784, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This book updates and adds to the classic Social Movements of the Sixties and Seventies, showing how social movement theory has grown and changed.

ABSTRACTMemory bias is a risk factor for depression. In two independent studies, the efficacy of one CBM-Memory session on negative memory bias and depressive symptoms was tested in vulnerable samples. We compared positive to neutral CBM-Memory trainings in highly-ruminating individuals and individuals with elevated depressive symptoms. In both studies, participants studied positive, neutral, and negative Swahili words paired with their translations. In five study–test blocks, they were then prompted to retrieve either only the positive or neutral translations. Immediately following the (...) training and one week later, we tested cued recall of all translations and autobiographical memory bias; and also measured mood, depressive symptoms, and rumination. Retrieval practice resulted in training-congruent recall both immediately after and one week after the training. Overall, there was no differential decrease in symptoms or difference in autobiographical memory bias between the tra... (shrink)

In an intrepid article entitled “Why Anselm's Proof in the Proslogion Is Not an Ontological Argument,”45 G.E.M. Anscombe takes issue with the traditional reading of Anselm's text. According to this reading Anselm's proof in Proslogion 2 depends upon the premise that existence is a perfection; and as a result of this dependency it has been given the label “ontological argument.” I In challenging the traditional reading, Anscombe proposes a corrected version of Anselm’s proof—a version which eliminates the premise that existence (...) is a perfection and which thereby undermines the rationale for considering the proof to be an “ontological argument.” Her corrected version runs as follows: 26 Anscombe on Anselm.. (shrink)

Begegnung des Verlegers mit Karl Jaspers, von K. Piper.-Philosophische Autobiographie, von K. Jaspers.- Jaspers und der Staat, von D. Sternberger.- Jaspers als geschichtlicher Denker, von G. Mann.- Jaspers in Frankreich, von J. Hersch.- Karl Jaspers und die italienische Philosophie, von L. Quattrocchi.- Die Philosophie von Karl Jaspers in Japan, von F. Hashimoto.-Karl Jaspers und der Rundfunk, von P. Meyer-Gutzwiller.- Karl Jasper's Lebensdaten.- Bibliographie der Werke und Schriften, von H. Saner [p.[173] -[216]].

In the most recent edition of Language, Truth and Logic , Professor A. J. Ayer still maintains that pure mathematics is analytic, being in fact merely a vast system of tautology. He is much more confident about this than are most contemporary professional mathematicians who have investigated the foundations of their subject. Following the breakdown of the efforts both of Frege and of Russell and Whitehead to derive pure mathematics from logic, i.e. to prove that the denial of any one (...) proposition of mathematics would necessarily be self-contradictory, Hilbert attempted to prove the more modest thesis that pure mathematics is consistent, i.e. that no two propositions of mathematics can contradict each other; but in 1931 Gödel discovered that even this thesis was undecidable according to the “rules of the game.” As Weyl has recently lamented, “From this history one thing should be clear: we are less certain than ever about the ultimate foundations of mathematics.” The sense in which Ayer uses the terms analytic and tautology implies also that in his view the activities of pure mathematicians lead to nothing new. It is true that he remarks that “there is a sense in which analytic propositions do give us new knowledge. They call attention to linguistic usages of which we might otherwise not be conscious, and they reveal unsuspected implications in our assertions and beliefs.” But, he continues, “we can also see that there is a sense in which they may be said to add nothing to our knowledge. For they may be said to tell us what we know already. ” This denial of novelty in mathematics is as typical of contemporary positivism as the prophecy of Comte that the composition of the stars would never be revealed to us and the objections of Mach to the atomic hypothesis were characteristic of nineteenth century positivism. Indeed, one wonders why the term positivism should have been appropriated by successive philosophers whose common outlook could be so much more fittingly described as negativism. (shrink)

The familiar issue of corporate social responsibility takes on a new topic. Added to the list of concerns from affirmative action and environmental integrity is their growing contributions to education. At first glance, the efforts may appear to be ordinary gestures of communal good will in terms of providing computers, sponsoring book covers, and interactive materials provided by Scholastic Magazine. A closer view reveals a targeted market of student life who are vulnerable to commercials placed in these formats. Among the (...) most effective corporate intervention is Channel One News. It offers a newsworthy show but with mandatory commercial viewing. This increasing trend of corporations intervening to assist schools that need more money and/or equipment is disingenuous.In this essay, I present the background of this commercialization of education and demonstrate the violations against student autonomy and integrity. Although there may be utilitarian merits to some interventions, I argue that these infringe upon the moral value of personhood. Advertising in schools in its current practice is immoral on deontological grounds. (shrink)

There is great skepticism about the admittance of expert normative ethics testimony into evidence. However, a practical analysis of the way ethics testimony has been used in courts of law reveals that the skeptical position is itself based on assumptions that are controversial. We argue for an alternative way to understand such expert testimony. This alternative understanding is based on the practice of clinical ethics.

In interpreting measurements of brain processes it is necessary to make the model used explicit. A concept such as attention cannot be used in the description of brain activities without a model of the relation of mental and neural processes.

Motor processes cannot be modeled by a single (unified) model. Instead, a number of models at different levels of description are needed. The concepts of control and control variable only make sense at the functional level. A clear distinction must be made between external models and internal models. General Systems Theory provides the framework for a proper treatment of these issues.

The cell assembly as a simple attractor cannot explain many cognitive phenomena. It must be a highly structured network that can sustain highly structured excitation patterns. Moreover, a cell assembly must be more widely distributed in space than on a square millimeter.

The information-theoretic point of view proposed by Leibniz in 1686 and developed by algorithmic information theory (AIT) suggests that mathematics and physics are not that different. This will be a first-person account of some doubts and speculations about the nature of mathematics that I have entertained for the past three decades, and which have now been incorporated in a digital philosophy paradigm shift that is sweeping across the sciences.

Dr Agich takes up a previous difficult case related by Dr Kottow in an earlier issue of the Journal. He analyses the three ethical problems as presented in the case and offers his own opinion of it as well as his own conclusions with regard to the medical ethical aspects of it. Unlike Dr Kottow, Dr Agich's reading of the case indicates that the application of the principle of informed consent does not rule out ethical decisions for the physician, but (...) emphasizes the relevance of ethical analysis beyond the issue of informed consent. (shrink)

This article is an attempt to clarify a confusion in the brain death literature between logical sufficiency/necessity and natural sufficiency/necessity. We focus on arguments that draw conclusions regarding empirical matters of fact from conceptual or ontological definitions. Specifically, we critically analyze arguments by Tom Tomlinson and Michael B. Green and Daniel Wikler. which, respectively, confuse logical and natural sufficiency and logical and natural necessity. Our own conclusion is that it is especially important in discussing the brain death issue to observe (...) the distinction between logical and natural sufficiency/necessity in a strict fashion. (shrink)

During the last decade neurotransplantation has developed into a technique with the possible potential to repair damaged or degenerating human brain. Effective neurotransplantation has so far been based on the use of fetal brain tissue derived from aborted embryos or fetuses. The ethical issues related to this new therapeutic approach therefore not only concern the possible adverse side effects for a neural graft-receiving patient, but also the relationship between the requirements for fetal tissue and the decision-making process for induced abortion. (...) Although for decades human embryos and fetuses have been the subject of biomedical studies, and, in principle, their use has therefore not been seen as ethically objectionable, the above points made it necessary to reconsider the moral issues. The present paper points out several of these issues, both from the donor and acceptor (patient) point of view. The conclusion is that under a series of restrictions intended to prevent the use of grafts from encouraging induced abortions and to maintain high standards of respect for life and human dignity, neurotransplantation using embryonic or fetal brain tissue parts cannot be rejected on moral grounds. (shrink)

Hi everybody! It's a great pleasure for me to be back here at the new, improved Santa Fe Institute in this spectacular location. I guess this is my fourth visit and it's always very stimulating, so I'm always very happy to visit you guys. I'd like to tell you what I've been up to lately. First of all, let me say what algorithmic information theory is good for, before telling you about the new version of it I've got.

Many biological systems experience a periodic environment. Floquet theory is a mathematical tool to deal with such time periodic systems. It is not often applied in biology, because linkage between the mathematics and the biology is not available. To create this linkage, we derive the Floquet theory for natural systems. We construct a framework, where the rotation of the Earth is causing the periodicity. Within this framework the angular momentum operator is introduced to describe the Earth’s rotation. The Fourier operators (...) and the Fourier states are defined to link the rotation to the biological system. Using these operators, the biological system can be transformed into a rotating frame in which the environment becomes static. In this rotating frame the Floquet solution can be derived. Two examples demonstrate how to apply this natural framework. (shrink)